Design SuperiorNutraceuticals WithData-Driven Simulation
Simulate the formulation that hits all required specs at the same time: activity, stability, shelf-life, bioavailability, cost, and more…
Trial and error, balancing many conflicting constraints
The project
A new R&D project is defined.
The targets
Target properties are defined, and they conflict. Fixing one ruins another.
The search
Hundreds of thousands of potential formulations. With expensive trial and error, only a few extremes can be tested.
The risk
Find that formulation and it still has to clear three more. Any one can end the program.
Backbond co-optimizes for all the targets simultaneously
- Texture
- Define a Number
- Stability
- Define a Number
- Bioavailability
- Define a Number
- Toxicity
- Define a Number
- Activity
- Define a Number
Define
The product and the targets it must hit. Product: Liposomal magnesium complex for sleep and recovery
Simulate
Backbond builds thousands of digital twins and evaluates every one against the targets.
Rank
Ranked by the best balance across every target, and flagged by how confident Backbond is in each.
Test
The team proceeds to the lab with the most promising formulations. By default, these satisfy all targets and constraints.
How Backbond simulates a formulation candidate
Four levels of physics decide what a formulation actually does, and Backbond reasons about how all four interplay to set every spec.
A few example use cases
Every one is the same shape: a handful of targets that fight each other, and one formulation that has to hit them all.
01Low-solubility actives
Curcumin barely dissolves. Find the carrier, particle size and emulsifier that raise absorption, while holding heat stability, colour and cost.
02Gastric survival
The active degrades in stomach acid before it can absorb. Find the coating, matrix and release trigger that deliver it intact to the intestine, while holding potency, disintegration and cost.
03Activity through processing
A botanical's active fraction is lost to heat and shear in drying and compression. Find the carrier, process window and protective system that preserve activity to expiry, while holding dose, format and cost.
04Unstable active forms
The form with the clinical effect is the least stable one. Find the salt, complex or encapsulation that hold the active form to end of shelf life, while keeping bioavailability, label claim and cost.
05Probiotic viability
Live cultures die in processing and on the shelf. Find the matrix, water activity and coating that hold CFU to 24 months, while keeping compressibility and gastric survival.
06Multivitamin interactions
Iron and copper degrade vitamin C in the same tablet. Find the coating and blend order that preserve every active to end of shelf life, while holding hardness and disintegration.
07UHT precipitation
Micellar casein precipitates in UHT. Find the casein grade, process parameters and excipient that ensure solubility, while holding encapsulation, shelf life and cost.
08Sugar-free gummies
Removing sugar collapses the gummy. Find the sweetener, humectant and gelling system that hold chew and shelf life, without polyol laxation or potency loss.
09Bitter actives
Magnesium and B-vitamins taste bitter and metallic. Find the masking system and coating that hide it, while holding disintegration time, clean label and cost.
10Titanium dioxide removal
TiO2 is out in the EU. Find the opacifier and coating that keep appearance and light protection, while holding the dissolution profile, printability and cost.